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Andrea Orcel began his career in 1987 at Midland Montagu in Fixed Income. In 1988 he moved to Goldman Sachs and in 1990 he joined The Boston Consulting Group.

From 1992 to 2012, Andrea worked for Merrill Lynch (then Bank of America), with a number of senior positions: Executive Chairman of the Investment Bank and President of Emerging Markets ex Asia (2009), President of International Global Banking, Securities & Wealth Management; Head of International Corporate and Investment Banking (2009), Head of Global Origination, President of EMEA Global Markets & Investment Banking and member of Merrill Lynch Management Committee (2007), Head of Origination and Co-President of Global Markets and Investment Banking for Europe, Middle East & Africa (2004), Head of Global Financial Institutions Group (2003), Co-Head of Financial Institutions Group for Europe, Middle East & Africa (1999).

In 2012, Andrea joined UBS as a Member of the Group Executive Board and then President, Investment Bank; then CEO, UBS Limited and UBS AG London Branch (2014); Member of the Board of UBS Americas Holding LLC, senior contact for US industry regulators and Senior Officer Outside of Australia and senior contact for Australia industry regulators (2016). He was also a Member of the Board of UBS Optimus Foundation, Senior Sponsor and Leader for Diversity and Talent Development in the Investment Bank and the UK.

On 15th April 2021, Andrea Orcel was appointed Group Chief Executive Officer of UniCredit.